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Research Projects
Developing of Biodegradable Biomaterials for Tissue Regeneration of Cardiovascular Tissues
The objective of this project is to use synthetic biodegradable
biomaterials to regenerate blood vessels in vivo.
The biomaterials will serve as temporary scaffolds in vivo
for human body to regenerate its own blood vessels.
This approach should eliminate the problems associated with
non-biodegradable synthetic vascular grafts. This design concept
can also be extended to tissue regeneration other than blood vessels.
The findings of this project were published in:
T. J. Yu, Donald M. Ho, & C. C. Chu, "Bicomponent Vascular
Grafts Consisting of Synthetic Biodegradable Fibers.
PART II. In Vivo Healing Response," J. Investigative Surg.
7:195-211 (1994).
T. J. Yu and C. C. Chu, "Bicomponent Vascular Grafts Consisting
of Synthetic Biodegradable Fibers. Part I. In Vitro Study."
J. Biomed. Mater. Res. 27:1329-1339, (1993).
C. C. Chu and L.E. Lecaroz, "Design and In Vitro Testing of
Newly-Made Bicomponent Knitted Fabrics for Vascular Surgery,"
In: Advances in Biomedical polymers, Charles G. Gebelein (Editor),
Polymer Science and Technology, Vol. 35, pp. 185-214, Plenum Press,
New York (1987). Also In: Surgical Research - Recent Developments,
C. William Hall (Editor), Pergamon Press, New York (1985),
pp. 46-49. Also In: Proceedings of the ACS Division of Polymeric
Materials: Science and Engineering, Vol. 53, pp. 400-404 (1985).
Keun-Ho Lee, C. C. Chu, J. Fred, "Aminoxyl-containing Radical
Spin Labeling In Polymers and Copolymers," U.S. Patent 5,516,881,
May 16, 1996.
Keun-Ho Lee, Chee-Youb Won and C. C. Chu, "Reactive Graft Polymer
with Biodegradable Backbone," U.S. Patent 5,610,241, March 11, 1997.
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