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Research Projects
Design of Biologically Active Biodegradable Biomaterials
The objective of this project is to chemically design
synthetic biodegradable biomaterials that would have
some biological activities so that they could "actively"
participate in the tissue reconstruction and repair.
All existing synthetic-based biomaterials do not actively
participate in tissue repair & wound healing and they only
act passive in terms of foreign body reactions.
We are exploring innovative chemical means to make these
biologically "inactive" biomaterials "active" after
implantation so that they could not only serve the functions
of the implant but also actively participate & promote the
healing and functions of the implants. The applications of
this class of new biomaterials would range from cardiovascular,
orthopaedic, skin, wound healing, to drug control/release devices.
This project has led to 2 US Patents so far and some of our
findings have recently been published.
Keun-Ho Lee and C. C. Chu, "Molecular design of biologically
active biodegradable polymers for biomedical applications",
Macromol. Symposium (Huthig & Wepf Verlag. Zug) 130: 71-80, (1998).
Chee-Youb Won, C. C. Chu, & J. D. Lee, "Synthesis and
Characterization of Novel Biodegradable Poly(L-aspartic acid-co-PEG)",
J.Polym. Sci., Chemistry Ed., 36:2949-2959, (1998).
Chee-Youb Won, C. C. Chu, & J. D. Lee, "Novel biodegradable
copolymers containing pendant amine functional groups based on
asparatic acid and poly(ethylene glycol)",
Polymer, 39(25): 6677-6681, (1998).
Chee-Youb Won & C. C. Chu, "Inulin polysaccharide having
pendant amino acids: Synthesis and characterization",
J. Appl. Polym. Sci., 70:953-963, (1998).
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